Crafted by world renowned gastroenterologist Dr. Will Bulsiewicz, Daily Microbiome Nutrition (DMN) offers unparalleled daily prebiotic support by blending cutting-edge science with Dr. B's clinical expertise.
Disturbance of the gut microbiome, also known as dysbiosis, is associated with most digestive disorders and numerous other health conditions. Restoring the microbiome is crucial to tackling the underlying cause of the issue.
Each core ingredient, drawn from three distinct classes of prebiotics, is chosen for its specific role in enhancing gut microbiome and overall bowel health.
Conscious of the link between digestive disorders and gut sensitivity, DMN was formulated low FODMAP (certified) to provide maximum benefit with minimum discomfort.
Ingredients list
Core ingredients
Potato (RS2 resistant starch)
Solnul 3500mg (proven dose) – Canada
Consumption of Solnul™ resistant potato starch produces a prebiotic effect in a randomized, placebo-controlled clinical trial.
Nutrients 2023; 15(7), 1582.
Resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeability.
Journal of Functional Foods Volume 108, September 2023, 105740
- Dose provided in the amount proven in human clinical trials.
- Resistant to digestive enzymes, it ferments in the large intestine, nourishing the microbiota.
- A study on 75 healthy adults shows a significant increase in Akkermansia and Bifidobacterium over four weeks with a daily intake of 3.5g of Solnul.
- Solnul: sustainably sourced, ancestral, evidence-based, low FODMAP, with proven prebiotic benefits.
Green Kiwifruit
Actazin 600mg (proven dose) – New Zealand
Actazin® green kiwifruit powder consumption at 600 mg per day for 28 days improves stool form and relieves occasional constipation in healthy individuals: a randomized controlled trial.
Bioactive Carbohydrates and Dietary Fibre, 2024;32:100436.
Kiwifruit-derived supplements increase stool frequency in healthy adults: a randomized, double-blind, placebo-controlled study.
Nutr Res J, 2015; 35:401-408
- Kiwifruit is rich in fiber, multiple polyphenols , digestive enzymes (actinidin), organic acids, vitamins and minerals.
- In two clinical studies, Actazin 600mg significantly increased weekly bowel movements.
- On May 7, 2021, the European Food Safety Authority deemed that based on the scientific evidence, green kiwifruit helps in the maintenance of normal defecation. The effect of Actazin 600mg is functionally equivalent.
2021 study: Actazin 600mg daily significantly increased Faecalibacterium in mild constipation.
Baobab & Acacia
Inavea 500mg – Africa
The Efficacy of Gum Arabic in Managing Diseases: A Systematic Review of Evidence-Based Clinical Trials.
Biomolecules. 2023 Jan 9;13(1):138.
Manipulation of Gut Microbiota Using Acacia Gum Polysaccharide.
ACS Omega. 2021 Jul 20; 6(28): 17782–17797.
Acacia Gum is a Bifidogenic Dietary Fibre with High Digestive Tolerance in Healthy Humans.
Microbial Ecology in Health and Disease, 15:1, 43-50.
Adansonia digitata L. (Baobab) Bioactive Compounds, Biological Activities, and the Potential Effect on Glycemia: A Narrative Review.
Nutrients. 2023 May; 15(9): 2170.
A Pectin-Rich, Baobab Fruit Pulp Powder Exerts Prebiotic Potential on the Human Gut Microbiome In Vitro.
Microorganisms. 2021 Sep 17;9(9):1981.
- A blend of two ancestral soluble dietary fibers, Acacia and Baobab.
- Source of bioactives such as gallic acid, (-)-epicatechin, epicatechin-3-gallate, procyanidin B2, tannins and carotenoids
- In an ex-vivo simulation of the human intestinal microbial ecosystem, 5g of the combination of Acacia + Baobab were found to exert significant prebiotic activity. The study showed the promotion of beneficial bacteria, including the Bifidobacterium spp., and specific bacteria families such as Akkermansiaceae and Christensenellaceae.Note that the trial was ex vivo and at a different dose, but these results along with other studies support the prebiotic nature of both Baobab and Acacia fiber.
- Certified Low FODMAP.
Lingonberry
Eevia 250mg
Whole fruit juice powder (on Acacia) – Finland
Lingongberry (Vaccinium vitis-idaea L.) Fruit as a source of bioactive compounds with health promoting effects - a review.
Int J Mol Sci 2021; 22(10):5126
Lingongberries alter the gut microbiota and prevent low-grade inflammation in high-fat diet fed mice.
Food Nutr Res 2016;60:29993
Lingongberries and their two separated fractions differently alter the gut microbiota, improve metabolic functions, reduce gut inflammatory properties, and improve brain function in ApoE-/-mice fed high-fat diet.
Nutr Neurosci 2020;23(8):600-612
- Wildcrafted and hand harvested from certified organic nordic forests.
- Lingonberry boasts the highest polyphenol/antioxidant (ORAC) value among berries.
- Contains polyphenols like proanthocyanidins, catechin, and epicatechin, supporting gut health and metabolic functions.
- Animal model studies indicate that the polyphenols in lingonberries alter the gut microbiota and reduce inflammation.
Beetroot
190mg powder – Poland
The Potential Benefits of Red Beetroot Supplementation in Health and Disease.
Nutrients. 2015 Apr; 7(4): 2801–2822.
A review on bioactive compounds of beet (Beta vulgaris L. subsp. vulgaris) with special emphasis on their beneficial effects on gut microbiota and gastrointestinal health
Crit Rev Food Sci Nutr. 2021;61(12):2022-2033.
Effect of two-week red beetroot juice consumption on modulation of gut microbiota in healthy human volunteers - A pilot study.
Food Chem. 2023 Apr 16:406:134989.
- Ideally grown in the fertile soils and cool temperatures of Poland as part of a centuries old food tradition.
- Source of multiple bioactive phytochemicals including betalains, flavonoids, polyphenols, Saponins and inorganic nitrate.
- Research indicates that beets contain a variety of bioactive compounds with the potential to positively alter the gut microbiota.
Mango
155mg powder – Australia
Mango (Mangifera indica L.) Polyphenols: Anti-Inflammatory Intestinal Microbial Health Benefits, and Associated Mechanisms of Actions.
Molecules. 2021 May; 26(9): 2732.
Mango Supplementation Modulates Gut Microbial Dysbiosis and Short-Chain Fatty Acid Production Independent of Body Weight Reduction in C57BL/6 Mice Fed a High-Fat Diet
J Nutr. 2016 Aug;146(8):1483-91.
Prebiotic effect of predigested mango peel on gut microbiota assessed in a dynamic in vitro model of the human colon (TIM-2).
Food Res Int. 2019 Apr:118:89-95.
- Polyphenols including mangiferin, benzoic acid, gallic acid, gallate, ellagic acid as well as quercetin.
- Several studies indicate that mango polyphenols have prebiotic effects and the potential to lower intestinal inflammation and promote intestinal barrier integrity.
Additional Ingredients
- Natural strawberry flavor 149mg
- Anhydrous silica 112mg
- Monk fruit powder 61mg
- Natural black currant flavor 44mg
- Powdered rice hull 29mg
Science
Prebiotics are food for your gut microbes and there are 3 main types – fiber, resistant starches, and polyphenols. All are deficient in the Western diet.
Distressed, nutritionally deficient microbial communities fall out of balance, which we call dysbiosis.
When the microbes are incapable of properly doing their job it affects how your body functions, contributing to the manifestation of disease.
Prebiotics are food for your gut microbes and there are 3 main types – fiber, resistant starches, and polyphenols. All are deficient in the Western diet.
Distressed, nutritionally deficient microbial communities fall out of balance, which we call dysbiosis.
When the microbes are incapable of properly doing their job it affects how your body functions, contributing to the manifestation of disease.
Science
Feed your microbes a mix of prebiotics.
Not only does DMN provide all 3 types of prebiotics, but it contains multiple sources from seven different plants. Variety is important in the microbiome!
Restore balance to the microbiome.
Fiber, resistant starch and polyphenols have all been shown to correct dysbiosis.
Normal bodily physiology returns when the microbiome is functional.
A healthy, nourished microbiome creates bioactive post-biotics that influence gut barrier integrity, bowel motility, immune function, metabolic health, and even cognition and mood.
Clinical studies
The studies that support our claims
Evidence first. Claims second.
DMN has a prebiotic effect.
Co-primaries: Actazin RCT, Solnul RCT
In separate RCTs using the doses found in DMN, Actazin 600mg/day increased Faecalibacterium (not F. prausnitzii) 140% over 28 days and Solnul 3.5g/day increased Akkermansia 317% and Bifidobacterium 350% over 28 days. Regular consumption of Actazin whole green kiwitfruit powder as well as Solnul resistant potato starch results in improved stool consistency and bowel habits in healthy individuals, thus conferring a health benefit and fulfilling the ISAPP definition of a prebiotic.
Prebiotic fibers in DMN are beneficial for intestinal microbiome health.
Co-primaries: Actazin RCT, Solnul RCT
As demonstrated by RCTs, both Actazin 600mg/day whole green kiwitfruit powder and Solnul 3.5g/day resistant potato starch are fiber containing foods fermented by the colonic microbiome that result in altered relative abundance of microorganisms and the health benefit of improved stool consistency in healthy individuals, they provide benefit to the health of the intestinal microbiome.
Nourishes healthy gut bacteria.
Co-primaries: Actazin RCT, Solnul RCT
As both Actazin 600mg/day and Solnul 3.5g/day are fiber containing foods fermented by the colonic microbiome that result in altered relative abundance of microorganisms, they foster and promote the growth of the microbiome and provide it with nutriment to increase in relative abundance, thus nourishing the gut bacteria.
DMN supports gut microbiome health.
Co-primaries: Actazin RCT, Solnul RCT
Actazin 600mg/day increased Faecalibacterium (not F. prausnitzii) 140% over 28 days and Solnul 3.5g/day increased Akkermansia 317% and Bifidobacterium 350% over 28 days.
DMN supports normal bowel function by promoting bowel regularity.
Primary: Actazin RCT
Actazin 600mg/day (the dose in DMN) leads to significant improvements in complete spontaneous bowel movements.
DMN can contribute to normal bowel function.
Co-primaries: Actazin RCT, Solnul RCT
Actazin 600mg/day leads to significant improvements in stool form and consistency and Solnul 3.5g/day reduces constipation and diarrhea- associated bowel movements, improving stool form.
Regular consumption of green kiwifruit aids gastrointestinal comfort.
Co-primaries: Actazin RCT 2015, Actazin RCT 2024
In two separate RCTs, Actazin 600mg/day (the amount found in DMN) produced clinically meaningful increases in bowel movements in healthy individuals.
There's a new, exciting world of scientific discovery in the microbiome. DMN is the fiber supplement that harnesses this new science, drawing from a variety of plant-based ingredients, to provide daily prebiotic support for a healthier microbiome.
