What does “microbiome diversity” actually mean?
Microbiome diversity refers to the variety and balance of microorganisms living in the gut — including bacteria, archaea, fungi, and viruses.¹²
A diverse microbiome isn’t about having more bacteria.
It’s about having many different microbial species performing complementary roles within a shared ecosystem.²³
This diversity allows the gut to remain resilient, adaptable, and stable over time.³⁴
Why diversity matters more than individual strains
In healthy ecosystems — from forests to coral reefs — diversity creates resilience. The gut microbiome works the same way.³
When microbial diversity is higher:
- Functional redundancy increases (multiple microbes can perform similar jobs)³
- The ecosystem adapts more easily to dietary or environmental changes⁴
- Disruptions are less likely to cascade into dysfunction³⁴
Low diversity, by contrast, can make the microbiome more fragile and reactive.⁴
What influences microbiome diversity?
Microbiome diversity is shaped by a range of factors, including:
- Diet quality and plant variety⁵⁶
- Fibre intake and fermentable substrates⁶⁷
- Antibiotic exposure⁸
- Stress, sleep, and circadian rhythm⁸
- Age and life stage¹
Of these, dietary inputs are one of the most modifiable drivers.⁵⁶
Diversity isn’t created by microbes alone
It’s a common misconception that diversity is built by adding microbes (for example, through probiotics).
In reality, diversity is more strongly influenced by:
- What microbes are fed⁶⁹
- Whether multiple species can be sustained long-term⁹
- Whether cross-feeding between microbes is supported¹⁰
Without sufficient fermentable fuel, introduced microbes rarely persist.⁸⁹
The role of fermentable fibres
Fermentable fibres act as ecological scaffolding for the microbiome.¹⁰¹¹
Different microbes prefer different substrates. When fibre sources are varied:
- More species can coexist¹⁰
- Cross-feeding networks are supported¹¹
- Metabolic output becomes more stable¹¹¹²
This is why diversity of inputs often matters more than microbial supplementation alone.⁹¹⁰
The takeaway
Microbiome diversity isn’t about chasing specific bacteria or maximising numbers.²³
It’s about supporting an ecosystem that can sustain itself.³⁴
That requires the right inputs, delivered consistently, in forms microbes can actually use.⁶¹⁰
References
-
Shreiner AB, Kao JY, Young VB.
The gut microbiome in health and in disease.
Current Opinion in Gastroenterology (2015).
DOI: https://doi.org/10.1097/MOG.0000000000000139
PubMed (abstract): https://pubmed.ncbi.nlm.nih.gov/25821943/
Free full text (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC4290017/ -
Lloyd-Price J et al.
Strains, functions and dynamics in the expanded Human Microbiome Project.
Nature (2017).
DOI: https://doi.org/10.1038/nature23889
Publisher page: https://www.nature.com/articles/nature23889 -
Coyte KZ, Schluter J, Foster KR.
The ecology of the microbiome: Networks, competition, and stability.
Science (2015).
DOI: https://doi.org/10.1126/science.aad2602
Publisher page: https://www.science.org/doi/10.1126/science.aad2602 -
Lozupone CA et al.
Diversity, stability and resilience of the human gut microbiota.
Nature (2012).
DOI: https://doi.org/10.1038/nature11550
Publisher page: https://www.nature.com/articles/nature11550 -
David LA et al.
Diet rapidly and reproducibly alters the human gut microbiome.
Nature (2014).
DOI: https://doi.org/10.1038/nature12820
Publisher page: https://www.nature.com/articles/nature12820 -
Sonnenburg ED et al.
Diet-induced extinctions in the gut microbiota compound over generations.
Nature (2016).
DOI: https://doi.org/10.1038/nature16504
Publisher page: https://www.nature.com/articles/nature16504 -
Makki K, Deehan EC, Walter J, Bäckhed F.
The impact of dietary fiber on gut microbiota in host health and disease.
Cell Host & Microbe (2018).
DOI: https://doi.org/10.1016/j.chom.2018.05.012
Publisher page: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(18)30160-0 -
Zmora N et al.
Probiotics colonize the gut mucosa in a host-specific manner.
Cell (2018).
DOI: https://doi.org/10.1016/j.cell.2018.08.041
Publisher page: https://www.cell.com/cell/fulltext/S0092-8674(18)31108-9 -
Walter J, Armet AM, Finlay BB, Shanahan F.
Establishing or exaggerating causality for the gut microbiome.
Cell (2020).
DOI: https://doi.org/10.1016/j.cell.2020.05.007
Publisher page: https://www.cell.com/cell/fulltext/S0092-8674(20)30532-1 -
Bindels LB et al.
Towards a more comprehensive concept for prebiotics.
Nature Reviews Gastroenterology & Hepatology (2015).
DOI: https://doi.org/10.1038/nrgastro.2015.47
Publisher page: https://www.nature.com/articles/nrgastro.2015.47 -
Flint HJ et al.
Links between diet, gut microbiota composition and gut metabolism.
Proceedings of the Nutrition Society (2012).
DOI: https://doi.org/10.1017/S0029665112000262
PubMed: https://pubmed.ncbi.nlm.nih.gov/22436128/ -
Makki K et al.
Dietary fiber, microbiota-derived metabolites, and host health.
Cell Host & Microbe (2018).
DOI: https://doi.org/10.1016/j.chom.2018.07.006
Publisher page: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(18)30221-6




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