A note from Dr. B
"Most constipation products treat one symptom with one ingredient. RCE works on three distinct mechanisms at once, because your gut deserves a complete solution, not a one-trick pony."
Dr. Will Bulsiewicz, MD MSCI Gastroenterologist & Co-Founder, 38TERA®
Three ingredients.
Three mechanisms.
RCE combines three clinically studied ingredients, each targeting a different part of the constipation picture. Because constipation is rarely caused by just one thing.
Each serving is 2 capsules. Each capsule delivers a clinically studied combination of three actives, each working on a separate mechanism.
Magnesium Oxide
Draws water into the bowel to soften stool and stimulate the body's natural urge to go — no cramping, no stimulant laxatives. MgO is included in clinical guidelines from the American Gastroenterological Association (2023) and British Dietetic Association (2025) for the management of chronic constipation.
GinFort™
A patented ginger extract standardised to over 26% gingerols and shogaols — the active polyphenols responsible for ginger's motility effects. Activates the gut's own movement signals. Eases the bloating and nausea that accompany constipation. In a 2022 double-blind, placebo-controlled clinical study, 64% of GinFort™ participants reported significant improvement in upper abdominal symptoms — vs. 13% on placebo — with results observed from Day 14.
Plenibiotic™ (next-generation postbiotic)
A heat-killed Lactobacillus casei 327 strain isolated from fermented brown rice. Shifts the microbiome toward beneficial bacteria and, in animal studies, supports the serotonin pathways involved in regular bowel function. As a heat-killed postbiotic, it doesn't need to survive transit to work — and is shelf-stable by design.
Stimulant-free by design. RCE contains no senna, bisacodyl, or other stimulant laxatives. No cramping. No urgency. No dependency risk. Gentle, consistent support across three mechanisms.
What RCE supports
- Bowel regularity*
- Relief from bloating and nausea*
- The gut environment for lasting regularity*
- Digestive side effects associated with GLP-1 medication use*
- Healthy digestion and digestive system function*
- Beneficial intestinal flora*
- Gut microbiome balance*
- No stimulant laxatives. No cramping. No habit formation.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
How RCE™ unfolds
over time
The three ingredients in RCE come online at different rates. Here is what the clinical evidence tells us about the timeline — and what you can realistically expect at each stage.
Ginger gets things moving — fast.
What's happeningWithin the first hour, concentrated gingerols in GinFort™ activate the gut's own motility signals — telling the digestive tract to get moving and helping with queasiness and fullness.
Magnesium oxide pulls water in.
What's happeningWhile you sleep, magnesium oxide draws water into the bowel — softening stool and prompting your body's natural urge to go. Many people notice a change within the first day or two.
All three mechanisms are now at work.
What's happeningBy the end of the first week, Plenibiotic™ is actively contributing to more regular bowel movements. It supports how gut bacteria trigger serotonin, the signal your body uses to keep things moving. With all three mechanisms working together, regularity follows.
The deeper change continues to build.
What's happeningBy the two-week mark, beneficial SCFA-producing bacteria rise while less helpful strains decline, and SCFA output increases. Plenibiotic™'s benefits continue to compound while magnesium oxide and GinFort™ support ongoing regularity. Your gut feels predictable. Bloating, discomfort, nausea and fullness are less frequent.
Complementary pieces for a healthier gut.
What's happeningConsistency builds the foundation. For deeper microbiome work, pair RCE with DMN. RCE's Plenibiotic™ supports motility signaling, while DMN's prebiotic and polyphenol blend feeds the bacteria themselves. Together, they support the gut at every level.
"Constipation is rarely caused by one thing. So I built RCE to work on three distinct mechanisms at once — because that's what the science supports, and that's what actually works."
— Dr. Will Bulsiewicz, MD, MSCI · Co-Founder, 38TERA®Start at 2 capsules.
Find your dose.
This is the standard dosing guide — the one most people need. Every gut is different, so the goal is to find the dose that keeps you comfortable and regular. Not too loose, not too sluggish.
2 capsules at bedtime
Take with a full glass of water, with or without food. MgO works gradually overnight, so many people notice a movement the next morning.
Give every dose 2 to 3 days
One or two doses will not tell you much. Judge a dose after 2 to 3 days, not after one night.
Move 1 capsule at a time
Need more support? Add a capsule. Too loose or too strong? Take one away. Small moves, then wait.
Never more than 4 in 24 hours
If you reach 4 capsules and nothing has changed, that is a conversation with your provider, not a fifth capsule.
Know your signal
You have found your dose when stools are softer, easier, and more predictable. Comfortable, formed, no straining.
You have gone one capsule too far when they are loose or urgent. That is not the product working better. That is your cue to ease back by one.
Hydration is part of the dose. MgO works by drawing water into the bowel. Underhydrated, the mechanism has less to work with and the dose underperforms. Aim for at least 8 glasses of water daily — more in warm weather or with exercise, and especially in your first two weeks.
How long until you can judge it
GinFort™ supports the gut's own motility signals soon after your first dose, and MgO works overnight, so many people notice a change in stool consistency within the first day or two. Plan on four weeks of consistent daily use to judge the full effect, over which bloating and fullness often become less frequent. Once you are going consistently, DMN™ is the natural next step.
Dr. B Clinical Note
Worth asking: why the constipation in the first place? If you are at 4 capsules daily for more than 7 days, or you have reached 4 capsules without improvement, that is worth a conversation with your healthcare provider — and worth asking specifically about pelvic floor dysfunction. It affects as many as 1 in 3 people with chronic constipation, often goes unrecognized, and will not respond to supplements or laxatives at any dose. The muscles are not relaxing and coordinating the way they should. The treatment is pelvic floor physical therapy, not a higher dose of anything.
Before you begin, read What to Know for the full list of who should not use RCE and when to contact your provider.
Using RCE for something specific?
The dosing above works for most people. But if you are coming off a daily laxative, managing digestion on a GLP-1 medication, or holding a rhythm you have already established, each of those calls for a slightly different approach. We have mapped out a step-by-step protocol for each one.
See the RCE protocols →Protocols for specific
symptoms and situations
These protocols do not replace the standard dosing above — they adapt it. Same capsules, same ceiling of 4 in 24 hours, same signal to watch for. What changes is where you start, how quickly you build, and what time of day you take it.
Open the one that best describes you.
Everyday relief You are constipated now and want a routine that works.
Your protocol is the standard dose, run consistently. RCE™ is built for daily use — the goal is not one dramatic result, it is finding the dose that keeps you comfortable and regular, then staying there.
Follow the standard dosing guide
2 capsules at bedtime, hold each dose 2 to 3 days, move 1 capsule at a time, never more than 4 in 24 hours. Full detail in Standard Dosing above.
Softer, easier, more predictable
Comfortable, not loose or urgent. When you get there, stop adjusting. That is your dose.
Stay consistent for four weeks
The clinical benefit in the ingredient studies came from daily use over weeks, not from occasional doses. Same time each day is easier to sustain than a schedule you have to think about.
Once you are going consistently, add DMN™
RCE gets things moving. DMN builds on that. Adding a lot of fermentable fiber before things are moving can leave you more bloated, so sequence matters.
Once you are settled, switch protocols
Getting regular and staying regular call for slightly different things. When your rhythm holds, move to Staying regular below and find your lowest effective dose.
Coming off laxatives You take a stimulant laxative most days and would rather not.
Do this one with your healthcare provider. Many people end up taking a stimulant laxative every day because it is the only thing that reliably works. It does. Most would still rather not depend on it, and many worry about becoming reliant on it.
The rule that makes this work
Build RCE up first. Step the laxative down second. Never both at once. If you reduce the laxative too early you fall behind, and the more backed up you get, the harder it is to catch up.
Get the foundations in place
Before changing anything: water consistently through the day, regular movement, and an unhurried window each morning to sit and let things happen.
Keep your laxative exactly as it is. Add 1 capsule of RCE™ in the evening
Full glass of water. Do not change your laxative dose yet.
Build gradually
No difference after 2 to 3 days? Go to 2 capsules, then 3 if needed. Give each level 2 to 3 days before moving up. Do not exceed 4 in 24 hours.
Watch for your signal
Softer, easier, more predictable. Comfortable, formed movements without straining. You are not aiming for loose or urgent — if you get there, ease back on the RCE.
Now step the laxative down, and step RCE up if you need it
Work with your doctor to reduce the laxative gradually rather than stopping all at once. As it comes down you can raise your RCE if you need a little more support. Hold at each level for several days before the next change.
Settle into your rhythm
People land in different places — some at 2 capsules a day, others at 3 or 4. Evening works best for most, since MgO works overnight and sets up a morning movement. If a larger dose feels crampy, or daytime bloating and nausea are your bigger issue, split it and take part earlier in the day.
Once you are regular, add DMN™
DMN is more than fiber. It supports the microbiome, bowel regularity, and stool form, all of which complement RCE. Sequence matters — adding a lot of fermentable fiber before things are moving can leave you more bloated.
Before you start this protocol
This plan is not for everyone. Do not use RCE to self-treat if you have kidney disease, a known or suspected bowel blockage, a history of fecal impaction, severe or worsening abdominal pain, significant bloating or distension, vomiting, blood in your stool, unexplained weight loss, or no bowel movement for several days. RCE™ is a dietary supplement, not a treatment for constipation, and it is not a substitute for medical care. Talk with your provider before changing any medication regimen, including over-the-counter laxatives.
On a GLP-1 Your medication slowed your digestion down.
GLP-1 medications slow digestion — that is how they work. RCE™ is designed to support you through that, and the right timing depends on which symptom is bothering you most.
First — when should you take it?
Before meals
1 capsule 20–30 minutes before your largest meal, so GinFort™ is working ahead of food.
Evening
MgO works overnight and sets up a movement in the morning.
Split it
Most of your dose in the evening, one capsule before your largest meal.
Then — how much?
1 capsule a day, with a full glass of water
At the time that matches your main symptom above. This is lower than the standard starting dose, because a slowed gut does better with a gentler ramp.
Work up to 2–3 capsules a day as tolerated
Give each level a couple of days. Do not exceed 4 in 24 hours. Some people land at 2, others at 3 or 4.
Softer, easier, more predictable
A larger evening dose can bring on a fairly urgent morning movement. That is expected. Aim for comfortable and regular, not loose.
Once you are stable and regular, consider adding DMN™
For ongoing microbiome support.
Already taking a laxative most days?
Do not stop it and expect RCE to fill the gap immediately. Follow Coming off laxatives above, which builds RCE up first and steps the laxative down once things are clearly moving.
On a GLP-1, these need a call — not a higher dose
Severe or worsening abdominal pain, persistent vomiting, or no bowel movement for several days. On a GLP-1 these can signal a serious slowdown. Contact your provider. If your GLP-1 is an oral tablet, keep RCE several hours apart from it.
Staying regular You are comfortable. Now you want to keep it that way.
Getting regular and staying regular call for slightly different things. Once your rhythm has settled, the work shifts from adjusting to maintaining.
Find your lowest effective dose, then hold it
Once you are consistently comfortable, you may not need the dose that got you there. Some people maintain on 2 capsules at bedtime, others settle at 1. Ease down by 1, give it 2 to 3 days, and see whether your rhythm holds. If it slips, step back up. Your maintenance dose is simply the smallest one that keeps things predictable.
Consistency matters more than dose size
The clinical benefit in the ingredient studies came from daily use over weeks, not from occasional doses. Same time each day is easier to sustain than a schedule you have to think about.
Keep hydration steady
The osmotic mechanism depends on it long term, not just during your first two weeks. If your rhythm slips for no obvious reason, water intake is the first thing to check.
Support the rhythm outside the bottle
Regular movement, adequate fiber from food, and an unhurried window at the same time each day all reinforce what RCE is doing. Dr. B is emphatic on that last one — routine matters more than most people expect.
Add DMN™ for the deeper layer
RCE's Plenibiotic™ supports motility signaling. DMN's prebiotic and polyphenol blend feeds the bacteria themselves. Most people take DMN in the morning and RCE at bedtime. There is no interaction between them and they are designed to work together.
Expect to flex, not to be finished
Travel, illness, diet changes, stress, and new medications can all disrupt a settled rhythm. That is normal and it does not mean you are starting over. Step your dose up temporarily, stay hydrated, and ease back down once things level out.
For travel specifically
Many people take 2 capsules the evening before departure or on the first day away. Keep a bottle in your carry-on and stay well hydrated, especially on flights.
Whichever protocol you follow, the limits in Standard Dosing still apply — never more than 4 capsules in 24 hours, and read What to Know before you begin.
Timing your RCE™
to match your goal
The time of day you take RCE can shift depending on what you're managing. Here are the approaches that work best.
Bedtime — Default Starting Point
Taking 2 capsules at bedtime with a large glass of water is the recommended starting point for most people. MgO works gradually overnight, and many people notice a bowel movement the following morning. This timing also separates the formula from meals, which suits the osmotic mechanism well.
Pre-Meal — When Nausea and Fullness Are the Issue
If nausea, early fullness, or post-meal bloating are what bother you most, take 1 capsule 20–30 minutes before your largest meal so GinFort™ is working ahead of food. This is common on a GLP-1 medication, though timing there depends on which symptom is dominant. See On a GLP-1 under RCE Protocols.
Split Dosing — When It's Both
If constipation and upper digestive discomfort are both in play, split the dose — most of it in the evening, one capsule before your largest meal. If a larger single dose feels crampy, splitting it helps there too.
Travel and Situational Use
RCE works well for travel or disrupted gut rhythm. Start with 2 capsules the evening before travel or on the first day away. Stay well hydrated — especially on flights. Keep a sample pack in your travel bag.
Consistency is what counts most. In the ingredient studies, benefits were seen within the first few weeks of daily use — one or two doses doesn't tell you much. A few weeks does.
RCE™ and GLP-1
medications
GLP-1 medications like semaglutide and tirzepatide can cause constipation, nausea, and bloating. RCE was formulated to support all three.
Why GLP-1 medications affect digestion
GLP-1 receptor agonists slow gastric emptying — food moves more slowly from the stomach into the small intestine. This supports appetite and blood sugar management, but it also means constipation, nausea, and post-meal bloating are commonly reported. Slower transit can compound these digestive effects over time.
If your digestion has slowed and you're dealing with constipation, bloating, or nausea, RCE supports comfortable, regular digestion — constipation (MgO osmotic softening), nausea and bloating (GinFort™ motility support), and gut microbiome disruption (Plenibiotic™).
"GLP-1 medications can be life-changing — but the digestive side effects are real. RCE was formulated to address not just the constipation, but the nausea and bloating too. Because you shouldn't have to sacrifice your gut comfort in order to achieve your health goals."
— Dr. Will Bulsiewicz, MD, MSCI · Co-Founder, 38TERA®How to use RCE on GLP-1 medication
Timing is the decision that matters most here, and it depends on which symptom is dominant. If nausea and fullness are the main issue, take RCE before meals so GinFort™ activates before food arrives in the stomach. If constipation is the bigger problem, take it in the evening so MgO works overnight. If it's both, split the dose.
The full protocol lives in one place
Step-by-step timing and dosing for GLP-1 users is in On a GLP-1, under RCE Protocols. If you are also taking a laxative most days, use Coming off laxatives instead, which builds RCE up before stepping the laxative down.
On a GLP-1, these need a call — not a higher dose
Severe or worsening abdominal pain, persistent vomiting, or no bowel movement for several days. On a GLP-1 these can signal a serious slowdown. Contact your provider. If your GLP-1 is an oral tablet, keep RCE several hours apart from it.
Dr. B Clinical Note
If you are on a GLP-1 medication and experiencing persistent digestive symptoms, please consult your prescribing provider. RCE is a dietary supplement, not a substitute for adjusting your medication protocol. Always disclose supplements to your healthcare provider.
A few things
before you begin
Practical information that helps you get the most from RCE — and know when to ask for help.
Hydration is non-negotiable
MgO draws water from your body into the bowel. If you're not adequately hydrated, the mechanism is less effective. Drink at least 8 glasses of water daily — more in warm weather or during exercise.
RCE is not a stimulant laxative
RCE works gently and builds over time. It does not create the urgency, cramping, or dependency risk of stimulant laxatives. Expect a gradual improvement in rhythm and comfort.
RCE pairs with DMN™
Start RCE first until your bowels are more regular. Then introduce DMN™ (Daily Microbiome Nutrition) for ongoing daily prebiotic support. Together, they support the foundations of a healthy gut.
Some causes will not respond to a supplement
Pelvic floor dysfunction affects as many as 1 in 3 people with chronic constipation, often goes unrecognized, and will not respond to supplements or laxatives at any dose. The treatment is pelvic floor physical therapy. If you have been at your maximum dose without improvement, it is worth getting evaluated.
When to talk to your provider
Do not use RCE if you have
Kidney disease. A known or suspected bowel obstruction. You are under 18.
Talk to your provider before starting if you
Are pregnant or breastfeeding. Take prescription medications. Have a history of fecal impaction. Have significant bloating or distension. Have constipation you have not yet discussed with them. Take a separate magnesium supplement — be mindful of your total daily magnesium intake.
Stop and contact your provider if you have
Rectal bleeding or blood in your stool. Severe or worsening abdominal pain. Persistent vomiting. Unexplained weight loss. No bowel movement after 7 days at your maximum dose.
Spacing
Keep RCE several hours apart from thyroid medication, some antibiotics, bone medications, and oral GLP-1 tablets.
RCE™ is a dietary supplement, not a treatment for constipation, and it is not a substitute for medical care. Always talk with your healthcare provider before starting a new supplement or changing any medication regimen, including over-the-counter laxatives.
Why one ingredient
isn't enough
Most constipation products treat one symptom with one ingredient. RCE is a daily support system that works on three mechanisms — without stimulants, cramping, or dependency.
| RCE™ | Osmotic laxatives | Stimulant laxatives | Magnesium only | |
|---|---|---|---|---|
| Active mechanisms Pathways targeted in the body | 3 | 1 | 1 | 1 |
| Gastroenterologist formulated | ✓ | ✕ | ✕ | ✕ |
| Dependency risk | None | None | Yes | None |
| Supports gut microbiome | ✓ | ✕ | ✕ | ✕ |
| Formulated for GLP-1 users | ✓ | ✕ | ✕ | ✕ |
| Common side effects | None or Mild | Bloating, gas | Cramping, urgency | None |
Common questions,
answered
Is RCE™ a laxative?
Not in the way most people think of laxatives. RCE contains magnesium oxide, which is classified as an osmotic agent — it draws water into the bowel rather than stimulating muscle contractions the way stimulant laxatives do. There is no cramping, no urgency, and no dependency risk. GinFort™ and Plenibiotic™ support motility and the microbiome through separate, non-laxative mechanisms.
How long before I notice a difference?
MgO can produce a shift in stool consistency within the first few days. GinFort™ shows significant clinical results from Day 14. Plenibiotic™ supports microbiome change across weeks one and two and continues to build. Plan for four weeks of consistent daily use to experience the full effect — and know that some benefits continue to develop beyond that point.
How do I know when I've found the right dose?
Your signal is stool becoming softer, easier, and more predictable — comfortable, formed movements without straining. You are not aiming for loose or urgent stools. If you get there, that is a sign to ease back by 1 capsule. Comfortable and regular is the target.
Does RCE™ need to be taken with food?
For general use: no. Bedtime on an empty stomach is fine, and often the most effective approach. If nausea, early fullness, or post-meal bloating are your main issue, take 1 capsule 20–30 minutes before your largest meal so GinFort™ can activate before food arrives. If constipation rather than nausea is the bigger problem, evening dosing works better.
I take a stimulant laxative every day. Can RCE replace it?
Work with your healthcare provider, and do not stop your laxative expecting RCE to fill the gap immediately. The approach is to build RCE up first while keeping your laxative unchanged, then step the laxative down gradually once your stools are clearly softer and more predictable. The full step-by-step is in Coming off laxatives, under RCE Protocols.
Can I take RCE™ and DMN™ together?
Yes — and we encourage it. Start RCE first to support bowel regularity. Once you're feeling more consistent, introduce DMN™ for ongoing daily prebiotic support. The two products work through complementary mechanisms and are designed to be used together.
Can I take RCE™ with my other supplements or medications?
RCE is generally compatible with most supplements and multivitamins. If you also take a magnesium supplement, be mindful of your total daily magnesium intake. Keep RCE several hours apart from thyroid medication, some antibiotics, bone medications, and oral GLP-1 tablets. Consult your healthcare provider if you are on prescription medications.
What if my stools become too loose?
Reduce by 1 capsule and allow 2–3 days to reassess. RCE's flexible dosing range is designed for this kind of calibration. Adjust down until you find comfortable, regular movement.
Can I take RCE™ every day indefinitely?
Yes. RCE is designed for daily ongoing use. It is non-habit-forming and stimulant-free. If you remain at 4 capsules daily for extended periods, it is worth a conversation with your healthcare provider — and worth asking specifically about pelvic floor dysfunction, a common and often-missed cause that will not respond to supplements or laxatives at any dose.
Does RCE™ need refrigeration?
No. Plenibiotic™ is a heat-killed postbiotic — shelf-stable by design. Store at room temperature away from direct sunlight and moisture.
Is RCE™ safe during pregnancy or while breastfeeding?
RCE has not been specifically studied during pregnancy or while breastfeeding. Consult your healthcare provider before use in this context.
I had a reaction — what should I do?
Your safety is our highest priority. Please reach out at support@38TERA.com or call 1.877.769.9965. Consistent with our refund policy, we will arrange a refund for the cost of the product minus shipping.
Key terms,
explained
Science-led communication means clarity over complexity. Here are the terms most relevant to your RCE™ journey.
- Osmotic Agent
- A compound that draws water into the intestines through osmotic pressure — increasing stool water content and volume to encourage bowel movement. MgO in RCE works this way. It is not a stimulant.
- Magnesium Oxide (MgO)
- A form of magnesium that draws water into the bowel to soften stool and support peristalsis. Included in clinical guidelines from the American Gastroenterological Association (2023) and British Dietetic Association (2025) for the management of chronic constipation.
- Peristalsis
- The rhythmic, wave-like contractions of the gut's smooth muscle that move food and waste through the digestive tract. GinFort™ supports the frequency and force of these contractions.
- GinFort™
- A patented ginger extract standardised to over 26% gingerols and shogaols — the key active polyphenols in ginger — using Aquasome technology for enhanced absorption. Clinically studied for upper digestive discomfort, with significant results from Day 14.
- Gingeroids / Shogaols
- The active polyphenols in ginger responsible for its digestive effects. They support gastric contraction frequency, help inhibit bowel smooth muscle spasm, and act on gut serotonin receptors to ease nausea.
- Dyspepsia
- Indigestion — the clinical term for upper digestive discomfort, including post-meal fullness, upper abdominal bloating, early satiation, and nausea. GinFort™ was clinically studied for upper-digestive comfort — bloating, fullness, and nausea.
- Pelvic Floor Dysfunction
- A condition in which the pelvic floor muscles do not relax and coordinate as they should during a bowel movement. It affects as many as 1 in 3 people with chronic constipation, often goes unrecognized, and does not respond to supplements or laxatives at any dose. The treatment is pelvic floor physical therapy.
- Postbiotic
- A preparation of non-viable (heat-killed) microorganisms that confers a health benefit. Plenibiotic™ is a postbiotic — it doesn't need to survive gut transit to exert its effects, making it inherently shelf-stable and consistent.
- Plenibiotic™
- The heat-killed Lactobacillus casei 327 postbiotic in RCE, isolated from fermented brown rice. Supports the gut microbiome toward SCFA-producing bacteria and supports colonic serotonin production.
- Short-Chain Fatty Acids (SCFAs)
- Compounds — acetate, propionate, butyrate — produced when gut bacteria ferment fiber. Important for gut barrier integrity and colonic cell function. Plenibiotic™ supports the bacteria responsible for producing these.
- Gut Microbiome
- The ecosystem of bacteria, fungi, viruses, and other microbes in the digestive tract — essential for digestion, immunity, metabolism, and bowel regularity.
- Serotonin (Gut)
- Around 95% of the body's serotonin is produced in the gut, where it plays a key role in regulating gastrointestinal motility. Plenibiotic™ has been shown in animal studies to support colonic serotonin production.
- GLP-1
- Glucagon-like peptide-1 — a hormone released naturally after meals. GLP-1 receptor agonists (a class of medications) mimic this hormone and slow gastric emptying, which supports appetite and blood sugar management but may cause constipation, nausea, and bloating as associated digestive effects.
- Gastric Emptying
- The process by which the stomach contracts to move digested food into the small intestine. GinFort™ supports the speed and efficiency of this process, which is relevant for those experiencing post-meal fullness and nausea.
Support your gut.
Restore your rhythm.
Formulated by gastroenterologist Dr. Will Bulsiewicz. Stimulant-free. Shelf-stable. Built to work with your body.
Shop RCE™Key References
- Mori H et al. Magnesium oxide in constipation. Nutrients 2021;13(2):421. doi.org/10.3390/nu13020421
- Kito Y et al. Efficacy of magnesium oxide for the treatment of functional constipation. J Neurogastroenterol Motil 2019;25(4):563–575. doi.org/10.5056/jnm18220
- Chang L et al. AGA-ACG Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation. Gastroenterology 2023;164(7):1086–1106. doi.org/10.1053/j.gastro.2023.02.030
- Dimidi E et al. British Dietetic Association Guidelines for Dietary Management of Chronic Constipation in Adults. J Hum Nutr Diet 2025;38(5):e70133. doi.org/10.1111/jhn.70133
- Panda SK et al. Randomised, double-blind, placebo-controlled study: GinFort in functional dyspepsia. J Diet Suppl 2022;19(2):226–237. doi.org/10.1080/19390211.2020.1855101
- Saito Y et al. Heat-killed Lactobacillus casei 327 on defecation in healthy volunteers. Biosci Microbiota Food Health 2018;37(3):59–65. doi.org/10.12938/bmfh.17-030
- Senda-Sugimoto Y et al. Lacticaseibacillus paracasei 327 on intestinal environment in healthy adults. Functional Foods Health & Disease 2024;14(3). PubMed
- Hara T et al. Heat-killed Lactobacillus casei 327 promotes colonic serotonin production in mice. J Functional Foods 2018;47:585–589. doi.org/10.1016/j.jff.2018.06.010
- PENDING — citation required for the "as many as 1 in 3" pelvic floor dysfunction prevalence figure used in Sections 03, 07 and 09. Add before publish, or soften the claim.
This guide is for educational and informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease. Always seek the advice of your healthcare provider about your specific health situation. Statements have not been evaluated by the Food and Drug Administration.
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