GI Doctor-Founded

RCE

Name: RCE™
Brand: 38TERA
SKU: RCE-60
Price: 59.99 USD
Availability: InStock
Rating: 4.2 (158 reviews)

REGULARITY & CONSTIPATION EASE

4.2

Rated 4.2 out of 5 stars

158 Reviews

A daily constipation relief formula that targets three root causes at once: osmotic relief, gut rhythm, and microbiome support. Backed by science, formulated by a gastroenterologist.

Supports bowel regularity*

Relieves bloating and nausea*

Promotes beneficial gut bacteria*

Helps counter constipation common with GLP-1 use*

Gentle on sensitive stomachs, powerful for your microbiome

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Clinically Dosed at Evidence-Based Levels

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Why Dr. B recommends thisBoard-Certified Gastroenterologist · NYT Bestselling Author of Fiber Fueled

"Constipation rarely has a single cause. That’s why RCE addresses three distinct mechanisms at once — because anything less is just treating a symptom."

Dr. Will Bulsiewicz, MD, MSCI — Board Certified Gastroenterologist

How to Use

How

2 capsules at bedtime with a full glass of water. With or without food. Adjust dose based on your body's response. If too strong, ease back to 1 capsule. Max 4 per day.

How much to start

On GLP-1? 1 capsule 20–30 min before your largest meal. Add as needed for relief. Max 4 per day.

Benefits

Gently draws water into the bowel to soften stool*
Supports your gut's natural rhythm and motility*
Restores the microbiome environment that healthy, regular bowel function depends on*
Addresses GLP-1 side effects — constipation, bloating, and nausea*
Non-habit-forming. Stimulant-free.*

Ingredients list

Magnesium (as magnesium oxide) — 430 mg • Zingiber officinale rhizome extract (GinFort®) — 200 mg • Lactobacillus casei postbiotic (Plenibiotic™) — 50 mg

Other ingredients: Hypromellose, rice flour, calcium laurate, bamboo silica.

View Supplement Facts

Supplement Facts

GI Doctor-Formulated
Gentle & Non-Habit Forming
Third-Party Tested
Non-GMO
No Refrigeration Required

THE CONSTIPATION GAP

Your gut isn't blocked. It's out of balance.

Constipation has three causes. Most products address one.

1 in 7

adults globally experience chronic constipation.

1 in 3

adults over 60 report chronic constipation — often undertreated.

2–3x

more common in women — driven by hormonal fluctuations.

#1

most disruptive GI side effect reported by GLP-1 medication users.

Your Gut Journey

How RCE unfolds over time

Each mechanism has its own activation window. Here’s what the clinical evidence shows — from your first dose forward.

Within the first hourGinfort® active · motility ↑

Ginger gets things moving — fast.

Within an hour of your first dose, concentrated gingeroids in Ginfort® activate the gut’s own motility signals. This is ginger’s prokinetic effect — well-established and rapid. The work has started.

OvernightMgO osmosis active

Stool softens

While you sleep, magnesium oxide draws water into the bowel — softening stool and prompting your body’s natural urge to go. Symptoms improve as regularity resumes, potentially as early as day one.

Day 7Plenibiotic™ engages

Microbiome has shifted

By the end of the first week, Plenibiotic™ is actively contributing to more regular bowel movements. It supports how gut bacteria trigger serotonin, the signal your body uses to keep things moving. With all three mechanisms working together, regularity follows.

Day 14Microbiome shifts established

The deeper change is locked in

By the two-week mark, beneficial SCFA-producing bacteria rise while less helpful strains decline, and SCFA output increases. Plenibiotic™’s benefits continue to compound while magnesium oxide and Ginfort® support ongoing regularity. Your gut feels predictable. Bloating, discomfort, nausea and fullness are less frequent.

OngoingRCE + DMN

Complementary pieces for a healthier gut

Consistency builds the foundation. For deeper microbiome work, pair RCE with DMN. RCE’s Plenibiotic™ supports motility signaling, while DMN’s prebiotic and polyphenol blend feeds the bacteria themselves. Together, they support the gut at every level.

CLINICAL EVIDENCE

Backed by evidence. Not just ingredient claims.

Every ingredient. Every dose. Each backed by its own randomized controlled trial. We don't follow the industry standard. We set a higher one.

Read the research

Start today

68-70%

Improvement in spontaneous bowel movements (MgO)

64%

Elimination of post-meal fullness & bloating (GinFort™)

Day 14

Measurable microbiome improvement (Plenibiotic™)

28 days

Results compound with full clinical evidence window for regularity

Magnesium Oxide

OSMOTIC RELIEF

430 mg

Gently draws water into the bowel, softening stool and prompting your body's natural urge to go without cramping or urgency.

Magnesium Oxide

Magnesium Oxide in the Treatment of Chronic Constipation: A Double-Blind, Randomised, Placebo-Controlled Study. J Neurogastroenterol Motil. 2019;25(4):563–575.

Magnesium Oxide vs Senna for Chronic Constipation: A Double-Blind Randomised Controlled Trial. Eur J Gastroenterol Hepatol. 2021. PubMed 32969946.

Magnesium Oxide for Functional Constipation: Evidence-Based Recommendations. Nutrients. 2021;13(2):421.

British Dietetic Association Dietary Management Guidelines for Chronic Constipation in Adults. J Hum Nutr Diet. 2025;38(5):e70133.

AGA-ACG Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation. Gastroenterology. 2023;164(7):1086–1106.

Osmotic laxative: draws water into the bowel to soften stool and stimulate a natural urge to go — without cramping, urgency, or stimulant effects.
2019 RCT (34 women, 28 days): 70% improved bowel movements with magnesium oxide vs 25% on placebo.
2021 RCT (90 patients, 28 days): comparable to Senna — 68.3% improvement vs 11.7% on placebo.
Recommended in both BDA and AGA-ACG clinical practice guidelines for chronic constipation.
Non-stimulant and non-habit-forming.

GinFort® Ginger Extract

GUT RHYTHM + COMFORT

200 mg

Activate the gut's own movement signals, restoring rhythm and keeping things moving.

GinFort® Ginger Extract

A Randomised, Double-Blind, Placebo-Controlled Study of GinFort™ in Subjects with Functional Dyspepsia. J Diet Suppl. 2022;19(2):226–237.

Effects of Ginger on Gastric Emptying and Motility in Healthy Humans. Eur J Gastroenterol Hepatol. 2008;20(5):436–440.

Effect of Ginger on Gastric Motility and Symptoms of Functional Dyspepsia. World J Gastroenterol. 2011;17(1):105–110.

Concentrated ginger root extract standardised to >26% gingeroids (shogaols and gingerols) — the active compounds responsible for motility and comfort effects.
2022 RCT (50 adults, 30 days): 64% eliminated post-meal fullness, bloating, and nausea with GinFort™ vs 13% on placebo.
Significant symptom relief observed from Day 14.
Activates the gut’s own motility signals — supporting gastric emptying and reducing upper GI discomfort without stimulant effects.
Particularly effective for GLP-1 users experiencing delayed gastric emptying, nausea, and early satiety.

Plenibiotic™

MICROBIOME RESTORATION

50 mg

Rebuilds the gut environment that lasting regularity depends on. Shifts the microbial balance toward beneficial, SCFA-producing bacteria.

Plenibiotic™

Effects of Lacticaseibacillus paracasei 327 Intake on the Intestinal Environment: A Randomised, Double-Blind, Placebo-Controlled Trial. Funct Foods Health Dis. 2024;14(3). DOI: 10.31989/ffhd.v14i3.1336.

Effects of Heat-Killed Lactobacillus casei 327 on Defecation in Healthy Volunteers: A Randomised, Double-Blind, Placebo-Controlled Study. Biosci Microbiota Food Health. 2018;37(3):59–65.

Heat-Killed Lactobacillus casei 327 Promotes Colonic Serotonin Synthesis in Mice. J Funct Foods. 2018;47:585–589.

Next-generation postbiotic — heat-killed L. casei 327, derived from fermented sources. Shelf-stable; no refrigeration required.
Unlike probiotics, postbiotics work with the bacteria already in your gut — no new strains introduced.
2024 RCT (110 healthy adults, 2 weeks): Plenibiotic™ significantly increased beneficial SCFA-producing bacteria (Bacteroides) and decreased less helpful strains (Clostridium cluster IV) vs placebo.
2018 RCT (104 adults, 2 weeks): significant improvement in bowel frequency with heat-killed L. casei 327 vs placebo.
Supports colonic serotonin production — the gut’s natural signal for regular, healthy motility.
No live organisms. Stable across temperature variation. Suitable for those with compromised immune systems.

Why Together

THE THREE-MECHANISM APPROACH

Relief that lasts requires more than one solution. RCE is the only formula built to address all three causes at once.

Why Together

Magnesium Oxide

Mori H et al. J Neurogastroenterol Motil. 2019;25(4):563–575. [2019 RCT — 70% vs 25%] https://pmc.ncbi.nlm.nih.gov/articles/PMC6786451/pdf/jnm-25-563.pdf

Mori H et al. Eur J Gastroenterol Hepatol. 2021. [2021 RCT — 68% vs 12%, comparable to Senna] https://pubmed.ncbi.nlm.nih.gov/32969946/

Mori H et al. Nutrients. 2021;13(2):421. [Mechanism review] https://pmc.ncbi.nlm.nih.gov/articles/PMC7911806/pdf/nutrients-13-00421.pdf

Dimidi E et al. J Hum Nutr Diet. 2025;38(5):e70133. [BDA Guidelines] https://pmc.ncbi.nlm.nih.gov/articles/PMC12517116/pdf/JHN-38-0.pdf

Chang L et al. Gastroenterology. 2023;164(7):1086–1106. [AGA-ACG Guidelines] https://pmc.ncbi.nlm.nih.gov/articles/PMC10542656/

GinFort®

Panda SK et al. J Diet Suppl. 2022;19(2):226–237. [Primary RCT — 64% vs 13%] https://pubmed.ncbi.nlm.nih.gov/33305631/

Wu KL et al. Eur J Gastroenterol Hepatol. 2008;20(5):436–440. https://pubmed.ncbi.nlm.nih.gov/18403946/

Hu ML et al. World J Gastroenterol. 2011;17(1):105–110. https://pmc.ncbi.nlm.nih.gov/articles/PMC3016669/

Plenibiotic™

Senda-Sugimoto Y et al. Funct Foods Health Dis. 2024;14(3). [Primary 2024 RCT — 110 adults, Day 14] https://www.ffhdj.com/index.php/ffhd/article/view/1336/3870

Saito Y et al. Biosci Microbiota Food Health. 2018;37(3):59–65. [2018 RCT — 104 adults] https://pmc.ncbi.nlm.nih.gov/articles/PMC6081609/

Hara T et al. J Funct Foods. 2018;47:585–589. [Serotonin / motility mechanism] https://www.sciencedirect.com/science/article/abs/pii/S1756464618302664

INFORMED CHOICE

How RCE compares

Built to work with your body, not override it.

Mechanisms

3

1

Gasterologist formulated

Dependency forming

No

Yes

No

Supports gut microbiome balance

Directly relieves nausea + bloating

Formulated for GLP-1

Side effect concerns

None

Bloating, gas, nausea

Cramping, diarrhea, habit-forming

None

Real People, Real Reviews

Slide 1 selected

Customers Talked About

Reviews Summary

Customers say this supplement helps them achieve regular bowel movements and reduces bloating. Many report improved consistency and relief from constipation, particularly those taking GLP-1 medications or dealing with chronic digestive issues. Common feedback includes needing time to find the right dosage, with most taking two capsules nightly. Some users experience loose stools initially or find it works best when paired with adequate hydration. A few note it doesn't work for their specific situation or causes discomfort.

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158 reviews

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Leslie M.
Verified Buyer
I recommend this product
What are you hoping to improve? Pick one that describes you best. Gut microbiome
Rated 5 out of 5 stars
23 seconds ago
TMI but I haven’t pooped this good in years, if ever.
I started with RCE and added DMN then BDR and honestly cannot believe how good I feel. My energy levels are through the roof. I’m regular and bloating has significantly reduced. I am a lifetime consumer of these products.
Was this helpful?
Cynthia G.
Verified Buyer
I recommend this product
What are you hoping to improve? Pick one that describes you best. Constipation
Rated 5 out of 5 stars
1 hour ago
My New Favorite Travel Companion
I consistently have regularity issues when I travel, especially when I'm a guest in someone's home or staying at a hotel and eating food that I don't eat at home. I have tried taking all kinds of fiber supplements with me, but nothing seems to work. I had resigned myself to accepting that my body is just a homebody.
Then RCE came along and I thought I'd give it a try. I used as directed on my last 8 day trip and never had a moment of discomfort or irregularity even though I didn't use any additional fiber supplements. As the old ad goes, from now on I won't be leaving home without it!
Was this helpful?
Billie H.
Verified Buyer
I recommend this product
What are you hoping to improve? Pick one that describes you best. Constipation
Rated 5 out of 5 stars
17 hours ago
This product works!
I bought this hoping it would help with GLP-1 constipation. It most certainly has. Now I have not taken it as the recommended instructions but 1 capsule a day is doing the trick for me so far. If it doesn't then I take the 2 capsules overnight. I don't prefer to take it this way as I do experience some cramping but as far as getting things moving this product does it. Will continue to purchase.
Was this helpful?
Jennifer M.
Verified Buyer
I recommend this product
What are you hoping to improve? Pick one that describes you best. Constipation
Rated 5 out of 5 stars
22 hours ago
Fabulous product
I love this product! As someone on a GLP, I have struggled with constipation issues and regular use of this product has cleared this up! I highly highly recommend!
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Evelyn A.
Verified Buyer
I recommend this product
What are you hoping to improve? Pick one that describes you best. Gut microbiome
Rated 5 out of 5 stars
5 days ago
Great product!
Great product for my needs! I'm much thankful for the comprehensive work that Dr. B and his colleagues have devoted to developing this product.
Was this helpful?

The Complete Gut Protocol

Start with RCE. Build with DMN.

RCE gets you regular. DMN keeps your microbiome thriving. Together, they support the foundations of a healthy gut.

Shop DMN

FAQS

You've got questions. We have answers.

ABOUT THE FORMULA

How is RCE different from a laxative?

Laxatives work on one mechanism. RCE works on three: osmotic relief (430 mg MgO softens stool), gut motility (200 mg GinFort® eases bloating and nausea), and microbiome restoration (50 mg Plenibiotic™ restores the gut environment regularity depends on). Non-habit-forming and stimulant-free.

The three mechanisms in full: osmotic relief (MgO draws water into the bowel), gut motility (GinFort® activates gut motility signals), and microbiome restoration (Plenibiotic™ shifts the microbial balance and supports serotonin-driven motility).

Can I take RCE with GLP-1 medication?

Yes — RCE was designed to alleviate GLP-1 symptoms. Rather than the standard bedtime dose, take 1 capsule 20–30 min before meals. Start with your largest meal; build to 2–3 meals/day as needed. Max 4 capsules daily. Consult your prescribing physician.

Is RCE habit-forming? Will I become dependent?

No. RCE is non-habit-forming and stimulant-free. Unlike stimulant laxatives that force a response, RCE works with your body's natural mechanisms — osmotically, through motility signals, and by restoring the microbiome environment healthy bowel function depends on.

What's the evidence behind the formula?

Four RCTs: MgO 70% vs 25% placebo (2019); MgO 68% vs 12%, comparable to Senna (2021); GinFort® 64% vs 13% (2022); Plenibiotic™ measurable microbiome improvement at Day 14 (2024). Read more about the science here.

What's the postbiotic in RCE and why does it matter?

Plenibiotic™ is a postbiotic — heat-killed L. casei 327. Unlike a probiotic, it works with the bacteria already in your gut: shifting the balance toward beneficial strains and supporting serotonin signals that regulate bowel rhythm. Measurable shift by Day 14.

Can I take RCE while pregnant or breastfeeding?

Consult your physician before taking RCE if you're pregnant, breastfeeding, or trying to become pregnant. Magnesium oxide, GinFort®, and Plenibiotic™ have not been specifically studied in pregnant or breastfeeding populations at the doses used in this formula.

USAGE & RESULTS

When will I feel results?

GinFort® activates within the first hour. MgO works overnight — many people notice a shift by morning. All three mechanisms are working together by Day 7. Lasting microbiome changes by Day 14.

How do I take RCE? Can I adjust the dose?

2 capsules at bedtime with a full glass of water. If stools are too loose or the effect feels too strong, ease back to 1 capsule. If you'd like more relief, increase by 1 capsule after 4 days, up to a maximum of 4 daily. If using 4 capsules for more than 7 days, consult your healthcare provider.

Can I take RCE and DMN on the same day?

Yes. DMN is taken once daily, any time that fits your routine, while RCE is taken at bedtime. Most people take DMN in the morning and RCE at night. There's no interaction between the two — they work on different mechanisms and are designed to complement each other.

ORDERS & SUBSCRIPTIONS

How does the subscription work? What's your return policy?

Subscription ships every 30 days. Cancel, pause, or change at any time — no fees. Not satisfied? 30-day money-back guarantee. Contact us within 30 days of your first purchase.

RCE

How RCE unfolds over time

Three causes of constipation. Three ingredients. One formula.

Magnesium Oxide

GinFort® Ginger Extract

Plenibiotic™

Why Together

Magnesium Oxide

GinFort®

Plenibiotic™

How RCE compares

You've got questions. We have answers.