RCE
RCE
RCE
RCE
RCE
RCE
RCE
RCE
RCE
Dr. Will Bulsiewicz
Why Dr. B recommends thisBoard-Certified Gastroenterologist · NYT Bestselling Author of Fiber Fueled

"Constipation rarely has a single cause. That’s why RCE addresses three distinct mechanisms at once — because anything less is just treating a symptom."

Dr. Will Bulsiewicz, MD, MSCI — Board Certified Gastroenterologist

THE CONSTIPATION GAP

Your gut isn't blocked. It's out of balance.

Constipation has three causes. Most products address one.

1 in 7

adults globally experience chronic constipation.

1 in 3

adults over 60 report chronic constipation — often undertreated.

2–3x

more common in women — driven by hormonal fluctuations.

#1

most disruptive GI side effect reported by GLP-1 medication users.

Your Gut Journey

How RCE unfolds over time

Each mechanism has its own activation window. Here’s what the clinical evidence shows — from your first dose forward.

Within the first hourGinfort® active · motility ↑
Ginger gets things moving — fast.

Within an hour of your first dose, concentrated gingeroids in Ginfort® activate the gut’s own motility signals. This is ginger’s prokinetic effect — well-established and rapid. The work has started.

OvernightMgO osmosis active
Stool softens

While you sleep, magnesium oxide draws water into the bowel — softening stool and prompting your body’s natural urge to go. Symptoms improve as regularity resumes, potentially as early as day one.

Day 7Plenibiotic™ engages
Microbiome has shifted

By the end of the first week, Plenibiotic™ is actively contributing to more regular bowel movements. It supports how gut bacteria trigger serotonin, the signal your body uses to keep things moving. With all three mechanisms working together, regularity follows.

Day 14Microbiome shifts established
The deeper change is locked in

By the two-week mark, beneficial SCFA-producing bacteria rise while less helpful strains decline, and SCFA output increases. Plenibiotic™’s benefits continue to compound while magnesium oxide and Ginfort® support ongoing regularity. Your gut feels predictable. Bloating, discomfort, nausea and fullness are less frequent.

OngoingRCE + DMN
Complementary pieces for a healthier gut

Consistency builds the foundation. For deeper microbiome work, pair RCE with DMN. RCE’s Plenibiotic™ supports motility signaling, while DMN’s prebiotic and polyphenol blend feeds the bacteria themselves. Together, they support the gut at every level.

CLINICAL EVIDENCE

Backed by evidence. Not just ingredient claims.

Every ingredient. Every dose. Each backed by its own randomized controlled trial. We don't follow the industry standard. We set a higher one.

Read the research
Start today

68-70%

Improvement in spontaneous bowel movements (MgO)

64%

Elimination of post-meal fullness & bloating (GinFort™)

Day 14

Measurable microbiome improvement (Plenibiotic™)

28 days

Results compound with full clinical evidence window for regularity

Three causes of constipation. Three ingredients. One formula.

Magnesium Oxide

OSMOTIC RELIEF

430 mg

Gently draws water into the bowel, softening stool and prompting your body's natural urge to go without cramping or urgency.

Magnesium Oxide

Magnesium Oxide in the Treatment of Chronic Constipation: A Double-Blind, Randomised, Placebo-Controlled Study. J Neurogastroenterol Motil. 2019;25(4):563–575.

Magnesium Oxide vs Senna for Chronic Constipation: A Double-Blind Randomised Controlled Trial. Eur J Gastroenterol Hepatol. 2021. PubMed 32969946.

Magnesium Oxide for Functional Constipation: Evidence-Based Recommendations. Nutrients. 2021;13(2):421.

British Dietetic Association Dietary Management Guidelines for Chronic Constipation in Adults. J Hum Nutr Diet. 2025;38(5):e70133.

AGA-ACG Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation. Gastroenterology. 2023;164(7):1086–1106.

  • Osmotic laxative: draws water into the bowel to soften stool and stimulate a natural urge to go — without cramping, urgency, or stimulant effects.
  • 2019 RCT (34 women, 28 days): 70% improved bowel movements with magnesium oxide vs 25% on placebo.
  • 2021 RCT (90 patients, 28 days): comparable to Senna — 68.3% improvement vs 11.7% on placebo.
  • Recommended in both BDA and AGA-ACG clinical practice guidelines for chronic constipation.
  • Non-stimulant and non-habit-forming.

GinFort® Ginger Extract

GUT RHYTHM + COMFORT

200 mg

Activate the gut's own movement signals, restoring rhythm and keeping things moving.

GinFort® Ginger Extract

A Randomised, Double-Blind, Placebo-Controlled Study of GinFort™ in Subjects with Functional Dyspepsia. J Diet Suppl. 2022;19(2):226–237.

Effects of Ginger on Gastric Emptying and Motility in Healthy Humans. Eur J Gastroenterol Hepatol. 2008;20(5):436–440.

Effect of Ginger on Gastric Motility and Symptoms of Functional Dyspepsia. World J Gastroenterol. 2011;17(1):105–110.

  • Concentrated ginger root extract standardised to >26% gingeroids (shogaols and gingerols) — the active compounds responsible for motility and comfort effects.
  • 2022 RCT (50 adults, 30 days): 64% eliminated post-meal fullness, bloating, and nausea with GinFort™ vs 13% on placebo.
  • Significant symptom relief observed from Day 14.
  • Activates the gut’s own motility signals — supporting gastric emptying and reducing upper GI discomfort without stimulant effects.
  • Particularly effective for GLP-1 users experiencing delayed gastric emptying, nausea, and early satiety.

Plenibiotic™

MICROBIOME RESTORATION

50 mg

Rebuilds the gut environment that lasting regularity depends on. Shifts the microbial balance toward beneficial, SCFA-producing bacteria.

Plenibiotic™

Effects of Lacticaseibacillus paracasei 327 Intake on the Intestinal Environment: A Randomised, Double-Blind, Placebo-Controlled Trial. Funct Foods Health Dis. 2024;14(3). DOI: 10.31989/ffhd.v14i3.1336.

Effects of Heat-Killed Lactobacillus casei 327 on Defecation in Healthy Volunteers: A Randomised, Double-Blind, Placebo-Controlled Study. Biosci Microbiota Food Health. 2018;37(3):59–65.

Heat-Killed Lactobacillus casei 327 Promotes Colonic Serotonin Synthesis in Mice. J Funct Foods. 2018;47:585–589.

  • Next-generation postbiotic — heat-killed L. casei 327, derived from fermented sources. Shelf-stable; no refrigeration required.
  • Unlike probiotics, postbiotics work with the bacteria already in your gut — no new strains introduced.
  • 2024 RCT (110 healthy adults, 2 weeks): Plenibiotic™ significantly increased beneficial SCFA-producing bacteria (Bacteroides) and decreased less helpful strains (Clostridium cluster IV) vs placebo.
  • 2018 RCT (104 adults, 2 weeks): significant improvement in bowel frequency with heat-killed L. casei 327 vs placebo.
  • Supports colonic serotonin production — the gut’s natural signal for regular, healthy motility.
  • No live organisms. Stable across temperature variation. Suitable for those with compromised immune systems.

Why Together

THE THREE-MECHANISM APPROACH

Relief that lasts requires more than one solution. RCE is the only formula built to address all three causes at once.

Why Together
Magnesium Oxide

Mori H et al. J Neurogastroenterol Motil. 2019;25(4):563–575. [2019 RCT — 70% vs 25%] https://pmc.ncbi.nlm.nih.gov/articles/PMC6786451/pdf/jnm-25-563.pdf

Mori H et al. Eur J Gastroenterol Hepatol. 2021. [2021 RCT — 68% vs 12%, comparable to Senna] https://pubmed.ncbi.nlm.nih.gov/32969946/

Mori H et al. Nutrients. 2021;13(2):421. [Mechanism review] https://pmc.ncbi.nlm.nih.gov/articles/PMC7911806/pdf/nutrients-13-00421.pdf

Dimidi E et al. J Hum Nutr Diet. 2025;38(5):e70133. [BDA Guidelines] https://pmc.ncbi.nlm.nih.gov/articles/PMC12517116/pdf/JHN-38-0.pdf

Chang L et al. Gastroenterology. 2023;164(7):1086–1106. [AGA-ACG Guidelines] https://pmc.ncbi.nlm.nih.gov/articles/PMC10542656/

GinFort®

Panda SK et al. J Diet Suppl. 2022;19(2):226–237. [Primary RCT — 64% vs 13%] https://pubmed.ncbi.nlm.nih.gov/33305631/

Wu KL et al. Eur J Gastroenterol Hepatol. 2008;20(5):436–440. https://pubmed.ncbi.nlm.nih.gov/18403946/

Hu ML et al. World J Gastroenterol. 2011;17(1):105–110. https://pmc.ncbi.nlm.nih.gov/articles/PMC3016669/

Plenibiotic™

Senda-Sugimoto Y et al. Funct Foods Health Dis. 2024;14(3). [Primary 2024 RCT — 110 adults, Day 14] https://www.ffhdj.com/index.php/ffhd/article/view/1336/3870

Saito Y et al. Biosci Microbiota Food Health. 2018;37(3):59–65. [2018 RCT — 104 adults] https://pmc.ncbi.nlm.nih.gov/articles/PMC6081609/

Hara T et al. J Funct Foods. 2018;47:585–589. [Serotonin / motility mechanism] https://www.sciencedirect.com/science/article/abs/pii/S1756464618302664

INFORMED CHOICE

How RCE compares

Built to work with your body, not override it.

RCE
Osmotic Laxatives
Stimulant Laxatives
Magnesium
Mechanisms

3

1
1
1
Gasterologist formulated
Dependency forming

No

No
Yes
No
Supports gut microbiome balance
Directly relieves nausea + bloating
Formulated for GLP-1
Side effect concerns

None

Bloating, gas, nausea
Cramping, diarrhea, habit-forming
None

Real People, Real Reviews

Slide 1 selected
Total 5 star reviews: 41 Total 4 star reviews: 9 Total 3 star reviews: 7 Total 2 star reviews: 7 Total 1 star reviews: 6
Customers Talked About
Reviews Summary
Customers say this supplement helps them achieve regular bowel movements and reduces bloating. Many report noticeable improvements within days to weeks, with some noting it works better than previous products they've tried. Common feedback includes reduced constipation and increased comfort. Some users mention needing dose adjustments or experiencing inconsistent results initially. A few report the capsule size is difficult to swallow, and some found no benefit. Overall, most reviewers express satisfaction with consistency and gentleness compared to other options.
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70 reviews
  • Johanna H.
    Flag of United States
    Verified Buyer
    I recommend this product
    What are you hoping to improve? Pick one that describes you best. Gut microbiome
    Rated 5 out of 5 stars
    1 minute ago
    It took 3 weeks but it changed everything.

    I took RCE for about 3 weeks , with not much change in my constipation. On again, off again. However, into the 3rd week, much to my delight, I became much more regular. I am now several weeks past that initial start of RCE, and my bowels have found their rhythm. I, also, consume DMN daily. I am so grateful.

    Was this helpful?
  • Lauren P.
    Flag of United States
    Verified Buyer
    I recommend this product
    What are you hoping to improve? Pick one that describes you best. Bloating
    Rated 5 out of 5 stars
    Yesterday
    Bloat Ease

    I was having a lot of issues with bloating . I eat whole-food plant based and a ton of fiber every day. But I grew up very stressed and eating a lot of crappy food, and my gut needed some extra help. And this worked out perfectly. After two weeks my bloating was down significantly. And it's been crucial to help me have bowel movements while traveling.

    Was this helpful?
  • Lynn S.
    Flag of United States
    Verified Buyer
    I recommend this product
    What are you hoping to improve? Pick one that describes you best. Something else
    Rated 5 out of 5 stars
    4 days ago
    Found my solution!

    RCE has improved my regularity. I have suffered from incomplete evacuation, gas and bloating. Tried fiber laxatives as directed by physician without resolution.... only more gas & bloating. Nothing worked! No 30 days into RCE I'm so excited that morning evacuation is complete and no looser poops and runs to the bathroom.

    Was this helpful?
  • Dana K.
    Verified Buyer
    I recommend this product
    What are you hoping to improve? Pick one that describes you best. Constipation
    Rated 5 out of 5 stars
    4 days ago
    Truly amazed!

    I've only been taking RCE for about a week, but by day two I could already tell a difference. I'm amazed at the ease in which I am now able to just sit down and go every morning. Talk about a life changer! I take 2 pills before bed and I still feel like I'm not having complete movements yet, but each day I am able to go and it seems to be better than the last. Looking forward to feeling the full benefits of continued use. I will warn you, it may the Magnesium working, but my partner has complained about the loud gurgling coming from my stomach waking him up 😂. The glass packaging isn't my favorite, but I plan to toss in the recycle bin.

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  • Roberta D.
    Flag of United States
    Verified Buyer
    I recommend this product
    What are you hoping to improve? Pick one that describes you best. Constipation
    Rated 4 out of 5 stars
    5 days ago
    The only thing that has worked!

    This is really the only thing I have used that has given me daily regularity! My only complaint is the pill is hard to swallow and I end up inhaling some particles that cause me to choke and cough. Also the packaging seems expensive, adding to the cost. But I will keep taking this because it’s like a miracle for me.

    Was this helpful?
The Complete Gut Protocol

Start with RCE. Build with DMN.

RCE gets you regular. DMN keeps your microbiome thriving. Together, they support the foundations of a healthy gut.

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