RCE™
RCE™
RCE™
RCE™
RCE™
RCE™
RCE™
RCE™
RCE™
Dr. Will Bulsiewicz
Why Dr. B recommends thisBoard-Certified Gastroenterologist · NYT Bestselling Author of Fiber Fueled

"Constipation rarely has a single cause. That’s why RCE addresses three distinct mechanisms at once — because anything less is just treating a symptom."

Dr. Will Bulsiewicz, MD, MSCI — Board Certified Gastroenterologist

THE CONSTIPATION GAP

Your gut isn't blocked. It's out of balance.

Constipation has three causes. Most products address one.

1 in 7

adults globally experience chronic constipation.

1 in 3

adults over 60 report chronic constipation — often undertreated.

2–3x

more common in women — driven by hormonal fluctuations.

#1

most disruptive GI side effect reported by GLP-1 medication users.

Your Gut Journey

How RCE unfolds over time

Each mechanism has its own activation window. Here’s what the clinical evidence shows — from your first dose forward.

Within the first hourGinfort® active · motility ↑
Ginger gets things moving — fast.

Within an hour of your first dose, concentrated gingeroids in Ginfort® activate the gut’s own motility signals. This is ginger’s prokinetic effect — well-established and rapid. The work has started.

OvernightMgO osmosis active
Stool softens

While you sleep, magnesium oxide draws water into the bowel — softening stool and prompting your body’s natural urge to go. Symptoms improve as regularity resumes, potentially as early as day one.

Day 7Plenibiotic™ engages
Microbiome has shifted

By the end of the first week, Plenibiotic™ is actively contributing to more regular bowel movements. It supports how gut bacteria trigger serotonin, the signal your body uses to keep things moving. With all three mechanisms working together, regularity follows.

Day 14Microbiome shifts established
The deeper change is locked in

By the two-week mark, beneficial SCFA-producing bacteria rise while less helpful strains decline, and SCFA output increases. Plenibiotic™’s benefits continue to compound while magnesium oxide and Ginfort® support ongoing regularity. Your gut feels predictable. Bloating, discomfort, nausea and fullness are less frequent.

OngoingRCE + DMN
Complementary pieces for a healthier gut

Consistency builds the foundation. For deeper microbiome work, pair RCE with DMN. RCE’s Plenibiotic™ supports motility signaling, while DMN’s prebiotic and polyphenol blend feeds the bacteria themselves. Together, they support the gut at every level.

CLINICAL EVIDENCE

Backed by evidence. Not just ingredient claims.

Every ingredient. Every dose. Each backed by its own randomized controlled trial. We don't follow the industry standard. We set a higher one.

Read the research
Start today

68-70%

Improvement in spontaneous bowel movements (MgO)

64%

Elimination of post-meal fullness & bloating (GinFort™)

Day 14

Measurable microbiome improvement (Plenibiotic™)

28 days

Results compound with full clinical evidence window for regularity

Three causes of constipation. Three ingredients. One formula.

Magnesium Oxide

OSMOTIC RELIEF

430 mg

Gently draws water into the bowel, softening stool and prompting your body's natural urge to go without cramping or urgency.

Magnesium Oxide

Magnesium Oxide in the Treatment of Chronic Constipation: A Double-Blind, Randomised, Placebo-Controlled Study. J Neurogastroenterol Motil. 2019;25(4):563–575.

Magnesium Oxide vs Senna for Chronic Constipation: A Double-Blind Randomised Controlled Trial. Eur J Gastroenterol Hepatol. 2021. PubMed 32969946.

Magnesium Oxide for Functional Constipation: Evidence-Based Recommendations. Nutrients. 2021;13(2):421.

British Dietetic Association Dietary Management Guidelines for Chronic Constipation in Adults. J Hum Nutr Diet. 2025;38(5):e70133.

AGA-ACG Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation. Gastroenterology. 2023;164(7):1086–1106.

  • Osmotic laxative: draws water into the bowel to soften stool and stimulate a natural urge to go — without cramping, urgency, or stimulant effects.
  • 2019 RCT (34 women, 28 days): 70% improved bowel movements with magnesium oxide vs 25% on placebo.
  • 2021 RCT (90 patients, 28 days): comparable to Senna — 68.3% improvement vs 11.7% on placebo.
  • Recommended in both BDA and AGA-ACG clinical practice guidelines for chronic constipation.
  • Non-stimulant and non-habit-forming.

GinFort® Ginger Extract

GUT RHYTHM + COMFORT

200 mg

Activate the gut's own movement signals, restoring rhythm and keeping things moving.

GinFort® Ginger Extract

A Randomised, Double-Blind, Placebo-Controlled Study of GinFort™ in Subjects with Functional Dyspepsia. J Diet Suppl. 2022;19(2):226–237.

Effects of Ginger on Gastric Emptying and Motility in Healthy Humans. Eur J Gastroenterol Hepatol. 2008;20(5):436–440.

Effect of Ginger on Gastric Motility and Symptoms of Functional Dyspepsia. World J Gastroenterol. 2011;17(1):105–110.

  • Concentrated ginger root extract standardised to >26% gingeroids (shogaols and gingerols) — the active compounds responsible for motility and comfort effects.
  • 2022 RCT (50 adults, 30 days): 64% eliminated post-meal fullness, bloating, and nausea with GinFort™ vs 13% on placebo.
  • Significant symptom relief observed from Day 14.
  • Activates the gut’s own motility signals — supporting gastric emptying and reducing upper GI discomfort without stimulant effects.
  • Particularly effective for GLP-1 users experiencing delayed gastric emptying, nausea, and early satiety.

Plenibiotic™

MICROBIOME RESTORATION

50 mg

Rebuilds the gut environment that lasting regularity depends on. Shifts the microbial balance toward beneficial, SCFA-producing bacteria.

Plenibiotic™

Effects of Lacticaseibacillus paracasei 327 Intake on the Intestinal Environment: A Randomised, Double-Blind, Placebo-Controlled Trial. Funct Foods Health Dis. 2024;14(3). DOI: 10.31989/ffhd.v14i3.1336.

Effects of Heat-Killed Lactobacillus casei 327 on Defecation in Healthy Volunteers: A Randomised, Double-Blind, Placebo-Controlled Study. Biosci Microbiota Food Health. 2018;37(3):59–65.

Heat-Killed Lactobacillus casei 327 Promotes Colonic Serotonin Synthesis in Mice. J Funct Foods. 2018;47:585–589.

  • Next-generation postbiotic — heat-killed L. casei 327, derived from fermented sources. Shelf-stable; no refrigeration required.
  • Unlike probiotics, postbiotics work with the bacteria already in your gut — no new strains introduced.
  • 2024 RCT (110 healthy adults, 2 weeks): Plenibiotic™ significantly increased beneficial SCFA-producing bacteria (Bacteroides) and decreased less helpful strains (Clostridium cluster IV) vs placebo.
  • 2018 RCT (104 adults, 2 weeks): significant improvement in bowel frequency with heat-killed L. casei 327 vs placebo.
  • Supports colonic serotonin production — the gut’s natural signal for regular, healthy motility.
  • No live organisms. Stable across temperature variation. Suitable for those with compromised immune systems.

Why Together

THE THREE-MECHANISM APPROACH

Relief that lasts requires more than one solution. RCE is the only formula built to address all three causes at once.

Why Together
Magnesium Oxide

Mori H et al. J Neurogastroenterol Motil. 2019;25(4):563–575. [2019 RCT — 70% vs 25%] https://pmc.ncbi.nlm.nih.gov/articles/PMC6786451/pdf/jnm-25-563.pdf

Mori H et al. Eur J Gastroenterol Hepatol. 2021. [2021 RCT — 68% vs 12%, comparable to Senna] https://pubmed.ncbi.nlm.nih.gov/32969946/

Mori H et al. Nutrients. 2021;13(2):421. [Mechanism review] https://pmc.ncbi.nlm.nih.gov/articles/PMC7911806/pdf/nutrients-13-00421.pdf

Dimidi E et al. J Hum Nutr Diet. 2025;38(5):e70133. [BDA Guidelines] https://pmc.ncbi.nlm.nih.gov/articles/PMC12517116/pdf/JHN-38-0.pdf

Chang L et al. Gastroenterology. 2023;164(7):1086–1106. [AGA-ACG Guidelines] https://pmc.ncbi.nlm.nih.gov/articles/PMC10542656/

GinFort®

Panda SK et al. J Diet Suppl. 2022;19(2):226–237. [Primary RCT — 64% vs 13%] https://pubmed.ncbi.nlm.nih.gov/33305631/

Wu KL et al. Eur J Gastroenterol Hepatol. 2008;20(5):436–440. https://pubmed.ncbi.nlm.nih.gov/18403946/

Hu ML et al. World J Gastroenterol. 2011;17(1):105–110. https://pmc.ncbi.nlm.nih.gov/articles/PMC3016669/

Plenibiotic™

Senda-Sugimoto Y et al. Funct Foods Health Dis. 2024;14(3). [Primary 2024 RCT — 110 adults, Day 14] https://www.ffhdj.com/index.php/ffhd/article/view/1336/3870

Saito Y et al. Biosci Microbiota Food Health. 2018;37(3):59–65. [2018 RCT — 104 adults] https://pmc.ncbi.nlm.nih.gov/articles/PMC6081609/

Hara T et al. J Funct Foods. 2018;47:585–589. [Serotonin / motility mechanism] https://www.sciencedirect.com/science/article/abs/pii/S1756464618302664

INFORMED CHOICE

How RCE compares

Built to work with your body, not override it.

RCE
Osmotic Laxatives
Stimulant Laxatives
Magnesium
Mechanisms

3

1
1
1
Gasterologist formulated
Dependency forming

No

No
Yes
No
Supports gut microbiome balance
Directly relieves nausea + bloating
Formulated for GLP-1
Side effect concerns

None

Bloating, gas, nausea
Cramping, diarrhea, habit-forming
None

Real People, Real Reviews

Slide 1 selected
Customers Talked About
Reviews Summary
Customers say this supplement helps them achieve regular bowel movements and reduces bloating. Many report improved consistency and relief from constipation, particularly those taking GLP-1 medications or dealing with chronic digestive issues. Common feedback includes needing time to find the right dosage, with most taking two capsules nightly. Some users experience loose stools initially or find it works best when paired with adequate hydration. A few note it doesn't work for their specific situation or causes discomfort.
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140 reviews
  • Zoila C.
    Flag of United States
    Verified Buyer
    I recommend this product
    What are you hoping to improve? Pick one that describes you best. Constipation
    Rated 5 out of 5 stars
    21 seconds ago
    Gently strong

    When I stopped taking it, I realized how much it really helped me.

    Was this helpful?
  • Joy G.
    Flag of United States
    Verified Buyer
    I recommend this product
    What are you hoping to improve? Pick one that describes you best. Bloating
    Rated 5 out of 5 stars
    3 days ago
    Finally, Gentle Relief That Works!

    I have a redundant colon and have dealt with digestive discomfort for years. Since taking RCE, I’ve finally had much less discomfort and my gut just feels less stressed overall. It’s been such a gentle relief for me, and I’m very happy with the difference I’ve noticed.

    Was this helpful?
    3 Profile picture for 38TERA
    38TERA
    2 days ago

    Thank you so much for sharing this, Joy! Years of digestive discomfort can really wear on you, so we're thrilled to hear your gut feels calmer and less stressed with RCE. We're so grateful to be part of your journey!

  • Marybeth A.
    Flag of United States
    Verified Buyer
    What are you hoping to improve? Pick one that describes you best. Gut microbiome
    Rated 3 out of 5 stars
    2 weeks ago
    A happy gut

    I was taking 2 capsules every day with 2 teaspoons of 38 Tera. I had mixed results. If I don’t drink enough water, walk my 2.5 to 3.5 miles, and eat enough fiber I have mixed results. I feel like I still need a dose of Calm every other day or so to stay regular, and I worry about too much magnesium.

    Was this helpful?
    3 Profile picture for 38TERA
    38TERA
    1 week ago

    Hi Marybeth, thank you for such a detailed review, it's really helpful to hear how water intake, walking, and fiber affect your results, that tracks with how RCE is designed to work best alongside those habits. On the magnesium question: RCE is formulated with magnesium as part of what supports regularity, and our guidance is not to exceed 4 capsules in a 24 hour period. If you have any kidney concerns or are combining RCE with other magnesium supplements, we'd recommend checking with your healthcare provider, since that's the main situation where magnesium intake needs extra care. Separating RCE from other magnesium products by a few hours can also help.

    Feel free to reach out to us directly at support@38tera.com if you'd like to talk through your specific routine. Thanks again for being part of the 38TERA community!

  • Vickie B.
    Flag of United States
    Verified Buyer
    I do not recommend this product
    What are you hoping to improve? Pick one that describes you best. Constipation
    Rated 2 out of 5 stars
    2 weeks ago
    Is it worth it?

    I have to take 4 RCE capsules to get any results. That makes it very expensive. It gives me alot of gas, so much that I wake up in the night with my gut churning.

    Was this helpful?
    3 Profile picture for 38TERA
    38TERA
    1 week ago

    Hi Vickie, thank you for the honest feedback, and we're sorry to hear about the gas and disrupted sleep, that doesn't sound comfortable at all. We'd love to help you figure out what's going on, please feel free to reach out to us directly at support@38tera.com so we can take a closer look at your experience.

  • Vonda J. C.
    Flag of United States
    Verified Buyer
    I recommend this product
    What are you hoping to improve? Pick one that describes you best. Food intolerances
    Rated 5 out of 5 stars
    2 weeks ago
    Wonderful!

    I can’t explain how RCE and DMN has changed my life. I have been struggling with my diet for years to find the right combination.

    I am weeks shy of being 67 yrs old a JRA & RA survivor. The medications that I have been on have distroyed my indigestion. I lived on a middle eastern diet until the age of 17 then introduced to an American diet living back stateside.

    Unless you know you don’t know simple things like yogurt or kefir differ in the US and other countries. Anyway I am so greatful and I really simple changes lead to bigger ones to feel better and have better health.

    Was this helpful?
The Complete Gut Protocol

Start with RCE. Build with DMN.

RCE gets you regular. DMN keeps your microbiome thriving. Together, they support the foundations of a healthy gut.

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