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GI DOCTOR-FORMULATED
You're losing weight. But your digestion feels like it's shut down — and most guidance doesn't explain why, or what actually helps.
The Constipation Gap
Your gut isn't blocked. It's out of balance.
Every mechanism in RCE is dosed to published clinical trial evidence — specific to the digestive friction GLP-1 medication creates.
#1
most disruptive GI side effect reported by GLP-1 medication users
1 in 7
adults globally experience occasional constipation
1 in 3
adults over 60 report occasional constipation — often undertreated
2-3x
more common in women — driven by hormonal fluctuations
THE GLP-1 REALITY
GLP-1s act on appetite.
The gut still needs support.
GLP-1 receptor agonists slow gastric emptying — food moves more slowly from the stomach into the small intestine. This supports appetite and blood sugar management, but it also means constipation and post-meal bloating are commonly reported. Slower transit can compound these digestive effects over time. If your digestion has slowed and you're dealing with occasional constipation and discomfort, that's the piece worth addressing directly — not just powering through.
RCE
Rated 4.2 out of 5 stars
113 Reviews
Daily microbiome nutrition, formulated by a gastroenterologist.
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The Formula
Three ingredients. Three mechanisms. Each working on a different root cause.
Most products address one symptom. RCE™ is built around the three places GLP-1 medications create digestive friction — at doses matched to the clinical evidence.
Magnesium Oxide
430 mg
Osmotic ReliefGently draws water into the bowel, softening stool and restoring the body's natural urge to go — without cramping, urgency, or stimulant effects.
GinFort® Ginger Extract
200 mg
Gut rhythm + ComfortConcentrated ginger extract standardized to >26% gingeroids. Activates the gut's own motility signals — easing post-meal fullness, bloating, and nausea.
Plenibiotic™
50 mg
Microbiome RestorationShifts the microbial balance toward beneficial, SCFA-producing bacteria. Measurable microbiome change by Day 14. Shelf-stable. No refrigeration.
How RCE™ unfolds
Each mechanism has its own activation window. Here's what the clinical evidence shows — from your first dose forward.
Within the first hour
Ginger gets things moving – fast
Within the first hour
Ginger gets things moving – fast
Taken before your meal, concentrated gingerols in GinFort™ activate the gut's own motility signals — telling the digestive tract to get moving and helping with queasiness and fullness right when GLP-1 slows things down most.
Within the first day
Stool softens
Within the first day
Stool softens
Magnesium oxide draws water into the bowel — softening stool and prompting your body's natural urge to go. Many people notice a change within the first day or two of consistent pre-meal dosing.
Day 7
All three mechanisms online
Day 7
All three mechanisms online
Plenibiotic™ begins contributing to bowel rhythm. Regularity becomes more consistent.
Day 14
The deeper change is locked in
Day 14
The deeper change is locked in
Beneficial SCFA-producing bacteria rise while less helpful strains decline. Your gut feels predictable — bloating, discomfort, nausea and fullness are less frequent.
Ongoing
Complementary pieces for a healthier gut
Ongoing
Complementary pieces for a healthier gut
Consistency builds the foundation. For deeper microbiome work, RCE™ pairs with DMN® — RCE™'s Plenibiotic™ supports motility signaling while DMN®'s prebiotic and polyphenol blend feeds the bacteria themselves.
Informed choice
How RCE™ compares.
Built to work with your body, not override it.
RCE
Osmotic laxatives
Stimulant laxatives
Magnesium alone
Mechanisms addressed
3
1
1
1
Gastroenterologist formulated
Yes
-
-
-
Formulated for GLP-1
Yes
Dependency forming
No
No
Yes
No
Supports gut microbiome balance
Yes
Directly relieves nausea + bloating
Yes
Notable considerations
Non-habit-forming, stimulant-free
Bloating, gas, nausea
Cramping, diarrhea, habit-forming
None
Start RCE.
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- Gastroenterologist-Formulated
- NSF Certified for Sport®
- Third-Party Tested
- Non-GMO
- 30-Day Money-Back Guarantee
FAQS
GLP-1 and RCE — answered directly.
How is RCE™ different from a laxative?
Laxatives work on one mechanism. RCE™ works on three: osmotic relief (430 mg MgO softens stool), gut motility (200 mg GinFort™ eases bloating and nausea), and microbiome restoration (50 mg Plenibiotic™ restores the gut environment regularity depends on). Non-habit-forming and stimulant-free.
Can I take RCE™ with my GLP-1 medication?
Yes — RCE™ was designed to alleviate the digestive side effects that often come with GLP-1 medications, like constipation, bloating, and nausea. It works through three mechanisms at once: magnesium oxide softens stool, GinFort™ (concentrated ginger extract) supports gut motility and eases bloating and nausea, and Plenibiotic™ (a postbiotic) supports your microbiome and the pathways tied to healthy, regular movement. If you're on a GLP-1, take 1 capsule 20–30 minutes before meals, starting with your largest meal of the day, and build up to 2–3 meals per day as needed. The maximum is 4 capsules daily. We'd also encourage you to check in with your prescribing physician, since they can give you the best guidance for your situation.
Is RCE™ habit-forming? Will I become dependent?
No. RCE™ is non-habit-forming and stimulant-free. Unlike stimulant laxatives that force a response, RCE™ works with your body's natural mechanisms — osmotically, through motility signals, and by restoring the microbiome environment healthy bowel function depends on.
Does RCE™ have to be taken at bedtime with a full glass of water?
It's generally recommended to take RCE™ with a glass of water. That said, it's still possible to maintain hydration throughout the day and take RCE™ with less water, or to take it earlier — such as around dinner time — rather than at bedtime. If you're on a GLP-1, the pre-meal approach above is the one designed for your situation. For questions related to your specific health history, it's best to discuss with your healthcare provider.
When will I feel the results?
GinFort™ activates within the first hour of your first pre-meal dose. MgO works within the first day — many people notice a shift by morning after starting. All three mechanisms are working together by Day 7. Lasting microbiome changes by Day 14.
How do I take RCE™? Can I adjust the dose?
Start with 1 capsule 20–30 minutes before your largest meal. If stools are too loose or the effect feels too strong, take it every other day instead. For more relief, add a capsule before a second meal after a few days, up to a maximum of 4 daily. If using 4 capsules for more than 7 days, consult your healthcare provider.
What's the evidence behind the formula?
Four randomized controlled trials support the formula: magnesium oxide at 70% vs 25% placebo (2019) and 68% vs 12% placebo, comparable to Senna (2021); GinFort™ at 64% vs 13% placebo (2022); and Plenibiotic™ showing measurable microbiome improvement by Day 14 (2024).
Can I take RCE™ while pregnant or breastfeeding?
Consult your physician before taking RCE™ if you're pregnant, breastfeeding, or trying to become pregnant. The formula's ingredients have not been specifically studied in these populations at the doses used.